Nicholas Runcie

DPhil in Statistics student

About Me

I completed my Integrated Master's (MChem) in Medicinal and Biological Chemistry at the University of Edinburgh. In my final year, I worked at AstraZeneca in oncology computational chemistry, contributing to small molecule drug discovery projects. There, I gained experience developing and applying AI methods to support drug discovery efforts.

Research Interests

My research focuses on developing artificial intelligence methods for small molecule drug discovery. The ultimate aim is to create tools that accelerate the discovery and development of novel medicines, addressing unmet medical needs more efficiently, cost-effectively, and with improved outcomes.

Currently, my research is centered around the application of large language models (such as ChatGPT, Claude, Gemini, etc.) in chemistry. I investigate whether these models truly "understand" chemistry and their potential to significantly aid scientific discovery. In particular, I am exploring how these models can leverage chemical theory to generate new hypotheses, design experiments, and interpret experimental results.

My first preprint as part of the Oxford Protein Informatics Group (OPIG) examines the ability of the latest large language models (known as reasoning models) to interpret molecular structures. Our findings demonstrate that these models can successfully perform highly complex chemistry tasks.

Selected publications:

Contact Details

Email: runcie@stats.ox.ac.uk

Office: 2.11

Pronouns: He/Him

Nikolas Baya

Postdoctoral Researcher

About Me

I am a postdoctoral researcher working with Dr. Duncan Palmer, continuing work from my DPhil involving the study of individuals with genetically-unexpected phenotypes in the UK Biobank. I was a DPhil student in the Genomic Medicine and Statistics programme run by the Wellcome Centre for Human Genetics, with my thesis co-supervised by Prof. Cecilia Lindgren and Prof. Simon Myers. Prior to Oxford, I graduated from Brown University with a degree in applied mathematics and worked for two years in the Neale Lab at the Broad Institute of MIT and Harvard.

Research Interests

Complex disease, polygenic scores, obesity, outliers, biomarkers, genome/exome-wide association studies, rare variant burden

Publications

Contact Details

Email: nikolas.baya@pmb.ox.ac.uk

Office: Big Data Institute

Pronouns: He/Him

Research Groups

Groups: Lindgren/Palmer

Junjie Chen

DPhil in Statistics student

About Me

I am a first-year DPhil student in the Department of Statistics and the Pandemic Science Institute at the University of Oxford. I completed my MSc in Modelling for Global Health (2023/2024) at Oxford and hold a BSc in Economics and Statistics (2020-2023) from University College London, where I developed a strong interest in statistical modeling and public health. My current research focuses on using mathematical tools to better understand mosquito-borne diseases and to inform more effective vector control strategies. Additionally, I am involved in a project that applies statistical analysis and software development to interpret serological data. My work integrates advanced statistical methods, mathematical modeling, and computational techniques to better understand disease transmission and contribute to public health strategies.

Research Interests

  • Mosquito-borne diseases
  • Mathematical biology
  • Serological data analysis
  • Statistical inference and Software development for infectious disease modelling
  • Public health applications, e.g., vaccine immunology

Dr Duncan Palmer

SMARTbiomed Senior Postdoctoral Researcher

About Me

I am a SMARTbiomed Senior Research Fellow, jointly based at the Big Data Institute (BDI) and the Department of Statistics. I co-lead the Biobank Rare-Variant Consortium (BRaVa), a collaborative effort involving 16 biobanks and cohorts (to date) from around the world to analyse rare genetic variation at scale to identify the genetic underpinnings of complex traits and disorders. I also co-lead the (gen)omics theme at the BDI.

I received an integrated master's degree in Mathematics and Statistics from the University of Warwick and a DPhil in Statistics from the University of Oxford, supervised by Professor Dame Angela McLean and Professor Gil McVean. I subsequently worked as a postdoctoral researcher with Professor Ben Neale, Dr Nick Patterson, and Professor Cecilia Lindgren at Massachusetts General Hospital, the Broad Institute, and the University of Oxford.

Research Interests

I develop and apply statistical and computational methods to gain insight into disease mechanisms. I am particularly interested in combining genetic, phenotypic and functional data to better refine association signals and understand the genetic architecture of complex traits. To this end, I collaborate with international partners to assemble and analyse large public datasets of human genetic variation.

As genetic sequencing datasets continue to grow, the tools we use must grow with them. My work also focuses on building scalable methods and computational approaches to analyse massive genetic datasets.

Publications

Contact Details

Email: duncan.palmer@stats.ox.ac.uk

Email: duncan.palmer@stats.ox.ac.uk

Pronouns: He/him

Research Groups

Gabriel Flath

DPhil in Statistics student

About Me

I am a third-year PhD student with broad interests in probability theory, branching processes, random structures, and models from statistical physics. My current research focuses on the limiting behaviour of certain branching Brownian motion particle systems. Before starting my DPhil, I completed graduate studies at École Polytechnique and the University of Cambridge.

Research Interests

  • Branching processes
  • Brownian motion and random walks
  • Statistical physics

Although my research is primarily theoretical, probabilistic reasoning arises naturally in many problems. I especially enjoy discovering simple and visual arguments. I am always open to collaboration-please feel free to reach out!

Contact Details

College Affiliation: St John’s College

Email: gabriel.flath@stats.ox.ac.uk

Office: 3.02

Research Groups

Lei Fang

MRes in Statistics student

About Me

[e.g. educational background, biographical details]

Research Interests

[areas of research interest]

Contact Details

Email:

Office:

Pronouns:

Research Groups

Groups

Supervisor

Link to supervisor profile

Yining Fan

DPhil in Statistics student

About Me

I am a DPhil student in Statistics supervised by Prof. Pier Palamara. My primary interest is in complex trait analysis and association studies in large genomic datasets. Previously, I completed my Bachelor’s degree in Statistics and Computer Science at McGill University and an MSc in Statistical Science at the University of Oxford.

Research Interests

Statistical and population genetics; complex trait analysis; scalable methods for association studies in large genomic datasets.

Contact Details

Email: yining.fan@st-hughs.ox.ac.uk

Office: G.05

Supervisor

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