Professor Charlotte Deane MBE
Professor of Structural Bioinformatics
I lead the Oxford Protein Informatics Group (OPIG), a research group of over 20 people working on diverse problems across immunoinformatics, protein structure and small molecule drug discovery; using statistics, AI and computation to generate biological and medical insight.
I am currently the Chief Scientist of Biologics AI at Exscientia and co-director of the Systems Approaches to Biomedical Research Centre for Doctoral Training which I founded in 2009.
During the COVID-19 pandemic, I served on SAGE, the UK Government’s Scientific Advisory Group for Emergencies and acted as UK Research and Innovation’s COVID-19 Response Director.
I have held numerous senior roles at the University of Oxford and until recently was the Deputy Executive Chair of the UK’s Engineering and Physical Sciences Research Council.
In the 2022 Birthday Honours, I was appointed Member of the Order of the British Empire (MBE) for services to COVID-19 research.
My research covers several areas in protein structure prediction and protein interaction networks, combining both theoretical work and empirical analyses. We work on developing novel methodologies to understand and predict protein evolution, interaction, structure and function. Our work is focussed in the four main areas listed below:
- Protein structure
- Biological Networks
- Small molecules
In OPIG, we develop novel algorithms, tools and databases that are openly available to the community. These tools are widely used web resources and are also part of several Pharma drug discovery pipelines.
For more information about the research and members of the Oxford Protein Informatics Group, see our group web pages. A list of all software developed in my group can also be found here.
- Professor, Department of Statistics, University of Oxford (2008 - present)
- Chief Scientist of Biologics AI at Exscientia (2021 - present)
- Deputy Executive Chair of the Engineering and Physical Sciences Research Council (2019 - 2021)
- Scientific Expert, Scientific Advisory Group for Emergencies (SAGE) (2021)
- COVID Response Director, UK Research and Innovation (2020 – December 2021)
- Head of Department of Statistics (2015 - 2019)
- Deputy Head of the Mathematical Physical and Life Sciences (MPLS) Division (2018 - 2020)
- Associate Head (Research) of MPLS Division (2014 - 2019)
- Associate Head (Impact and Innovation) of MPLS Division (2013 – 2014)
- Director - Systems Approaches to Biomedical Research Centre for Doctoral Training (2009 - present)
- Director - Systems Biology Doctoral Training Centre (2007 – 2009)
- University Lecturer, Department of Statistics, University of Oxford (2002 - 2008)
- Welcome Trust Research Fellow, University of California Los Angeles (2000 - 2002)
- Video: Digital Futures - Royal Society of Chemistry
- Video: Oxford University Scientific Society (Lecture: The Protein Structure Universe: from Creation to Medicine)
- Podcast: Tech Tent on the BBC World Service (Interview on the role of AI in drug discovery)
- Podcast: Why aren't we dead? (Oxford Sparks)
- Video: Structurally mapping next generation sequencing repertoires of antibodies to aid in-silico therapeutic design (ELRIG Drug Discovery 2018)
- Video: Predicting Loop Conformational Ensembles (ISMB 2018)
- Video: The developability issues affecting the efficacy of therapeutic monoclonal antibodies ('LabTube meets' series)
- Video: The structural antibody database and its importance ('LabTube meets' series)
- Video: Exciting Scientists - interview with Winton Capital