Dr Oliver Crook

Florence Nightingale Bicentenary Research Fellow

About Me

Hi! I'm Olly a Junior Research Fellow at New College. I previosly did my PhD in Biochemistry in Cambridge with Kathryn Lilley and an MMath at Warwick. My work is primarily Bayesian computational methods to understand data rising from biologically motivated problems.

Research Interests

I develop statistical and machine learning methods for biochemical and biophysical data. My work spans both systems and structural biology with a focus on understanding how proteins function through the lens of computation. I make paritcular use of Bayesian non-parametrics and machine/deep learning.

Publications

Villanueva, E., Smith, T., Pizzinga, M., Elzek, M., Queiroz, R., Harvey, R., Breckels, L., Crook, O., Monti, M., Dezi, V., Willis, A. and Lilley, K. (2024) “System-wide analysis of RNA and protein subcellular localization dynamics.”, Nature methods, 21(1), pp. 60–71.

Jiang, Y., Rex, D., Schuster, D., Neely, B., Rosano, G., Volkmar, N., Momenzadeh, A., Peters-Clarke, T., Egbert, S., Kreimer, S., Doud, E., Crook, O., Yadav, A., Vanuopadath, M., Mayta, M., Duboff, A., Riley, N., Moritz, R. and Meyer, J. (2023) “Comprehensive Overview of Bottom-Up Proteomics using Mass Spectrometry.”, ArXiv [Preprint].

Crook, O., Gittens, N., Chung, C.-W. and Deane, C. (2023) “A Functional Bayesian Model for Hydrogen-Deuterium Exchange Mass Spectrometry.”, Journal of proteome research, 22(9), pp. 2959–2972.

Moloney, N., Barylyuk, K., Tromer, E., Crook, O., Breckels, L., Lilley, K., Waller, R. and MacGregor, P. (2023) “Mapping diversity in African trypanosomes using high resolution spatial proteomics.”, Nature communications, 14(1), p. 4401.

Guérin, A., Strelau, K., Barylyuk, K., Wallbank, B., Berry, L., Crook, O., Lilley, K., Waller, R. and Striepen, B. (2023) “Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell”, Cell Host and Microbe, 31(4), pp. 650 – 664.e6.

Crook, O., Warmbrod, K., Lipstein, G., Chung, C., Bakerlee, C., McKelvey, T., Holland, S., Swett, J., Esvelt, K., Alley, E. and Bradshaw, W. (2022) “Analysis of the first genetic engineering attribution challenge.”, Nature communications, 13(1), p. 7374.

Denholm, J., Schreiber, B., Evans, S., Crook, O., Sharma, A., Watson, J., Bancroft, H., Langman, G., Gilbey, J., Schönlieb, C.-B., Arends, M. and Soilleux, E. (2022) “Multiple-instance-learning-based detection of coeliac disease in histological whole-slide images”, Journal of Pathology Informatics, 13.

Crook, O., Davies, C., Breckels, L., Christopher, J., Gatto, L., Kirk, P. and Lilley, K. (2022) “Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE.”, Nature communications, 13(1), p. 5948.

Braccia, C., Christopher, J., Crook, O., Breckels, L., Queiroz, R., Liessi, N., Tomati, V., Capurro, V., Bandiera, T., Baldassari, S., Pedemonte, N., Lilley, K. and Armirotti, A. (2022) “CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium.”, Cells, 11(12), p. 1938.

Crook, O., Chung, C.-W. and Deane, C. (2022) “Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry.”, Communications biology, 5(1), p. 588.