About

I lead the Oxford Protein Informatics group, a research group of over 20 people working on diverse problems across protein structure, immunoinformatics, biological networks and small molecule drug discovery.

Positions and Employment

  • Deputy Executive Chair of the Engineering and Physical Sciences Research Council (2019-)
  • Head of Department of Statistics (2015-2019)
  • Deputy Head of the Mathematical Physical and Life Sciences (MPLS) Division (2018-2020)
  • Associate Head (Research) of MPLS Division (2014-2019)
  • Associate Head (Impact & Innovation) of MPLS Division (2013–2014)
  • Director - Systems Approaches to Biomedical Research Centre for Doctoral Training (2009-)
  • Director - Systems Biology Doctoral Training Centre (2007–2009)
  • Research Professor, Department of Statistics, University of Oxford (2008-)
  • University Lecturer, Department of Statistics, University of Oxford (2002-2008)
  • Welcome Trust Research Fellow, University of California Los Angeles (2000–2002)

Academic Qualifications

  • PhD - Jesus College, University of Cambridge
  • MA - Chemistry, University College, University of Oxford

Selected conference presentations (since 2014)

EBI Biologics (2014), SMBE (2014), Drug Discovery Summit (2014), Networks in biological sciences (2015), Gordon Conference Membrane Protein folding (2105), 3DSIG (2015), CCP4 (2016), PPS (2016), Americas Antibody Conference (2016), Gordon Conference CADD (2017), ISMB (2017), IEEE Computational Intelligence in Bioinformatics and Computational Biology (2017), ISMB (2018), Keynote RosettaCon (2018), UK QSAR (2019), PEGS America (2019), Gordon Conference Proteins (2019), PEGS Europe (2019), Cambridge networks day (2019), CCPBiosim (2019), ELRIG (2019)

Media

  • Video: Exciting Scientists - interview with Winton Capital [link]
  • Video: The structural antibody database and its importance ('LabTube meets' series) [link]
  • Video: The developability issues affecting the efficacy of therapeutic monoclonal antibodies ('LabTube meets' series) [link]
  • Video: Predicting Loop Conformational Ensembles (ISMB 2018) [link]
  • Video: Structurally mapping next generation sequencing repertoires of antibodies to aid in-silico therapeutic design (ELRIG Drug Discovery 2018) [link]
  • Podcast: Why aren't we dead? (Oxford Sparks) [link]
  • Podcast: Tech Tent on the BBC World Service (Interview on the role of AI in drug discovery) [link]
  • Video: Oxford University Scientific Society (Lecture: The Protein Structure Universe:from Creation to Medicine) [link]
  • Video: Digital Futures - Royal Society of Chemistry [link]

Research Interests

My research covers several areas in protein structure prediction and protein interaction networks, combining both theoretical work and empirical analyses. We work on developing novel methodologies to understand and predict protein evolution, interaction, structure and function. Our work is focussed in the four main areas listed below:

  • Protein structure
  • Immunoinformatics
  • Biological Networks
  • Small molecules
For more information about the research and members of the Oxford Protein Informatics Group, see our group web pages. A list of all software developed in my group can also be found here.