Computational Promoter Analysis of non-Coding RNAs

One of the major recent scientific surprises has been the discovery of a variety of functional RNAs and that a large fraction of the genome is under purifying selection. It is clear that a large fraction of RNAs is involved in gene regulation and is especially important in brain development. Optimal use of comparative genomics in this context presents two challenging problems: RNA gene identification and the characterisation of regulatory elements. The project focuses on the latter, which is likely to be a major challenge for quite some time to come and this project would easily scale to a complete PhD that would involve both methodology development and data analysis, besides yielding results of medical importance. However, it is also possible to formulate a pilot version, that is of interest in itself.