Phylogenetic Analysis of “New” Homeobox in the Lineage Leading to Humans
The homeobox genes are extremely interesting and central in the mechanisms establishing form in metazoans, so it is highly relevant tracing these genes evolutionary. Peter Holland's group has found 4 new genes in humans, by comparison to the mouse genome (Booth et al., 2006). Since this work the number of sequenced genomes have increased significantly and it should now be possible to date the origin of these genes much more precisely. Understanding homeobox genes is central in metazoan embryology. The project will imply genome annotation and phylogenetic analysis.