MCMC Integration over Evolutionary Histories of Metabolic Networks

Methods that could explore stochastic models that could calculate the likelihood of two homologous metabolic pathways by summing over all evolutionary histories that could relate them will be explored. Such a method would open the way for important data analysis, that is presently not possible or at least done by flawed methods: Parameter estimation in the evolutionary process of metabolic pathways, testing of hypotheses about the evolution of metabolic pathways and making statements about the path of evolution (ancestral analysis).