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Professor Jonathan Marchini

Professor of Statistical Genomics

Fellow at Somerville College

Statistical Genomics group

+44 (0)1865 272860 (Department)
+44 (0)1865 271125 (Direct)

Biographical Sketch

I studied Mathematics and Statistics at Exeter University from 1991-1994. I then trained as a secondary school Mathematics teacher for 1 year before working as a VSO volunteer in Tanzania for three years teaching A-level Mathematics. I came to Oxford in 1998 to do a Dphil on the statistical analysis of fMRI brain images supervised by Professor Brian Ripley. In 2002 I started to work in the area of statistical genetics as a postdoc supervised by Professor Peter Donnelly and Professor Lon Cardon. I became a University Lecturer in Statistical Genomics in September 2005. In 2012 I was awarded a Philip Leverhulme Research Prize. In 2013 I was awarded the title of Professor of Statistical Genomics. I am a Tutorial Fellow in Statistics at Somerville College. I currently hold an ERC Consolidator Award and a Wellcome Trust Collaborator Award.

Research Interests

  • Statistical Genetics
  • Genome-wide Association Studies
  • Imaging-Genetics
  • Multi-Omic Data Integration
  • Computationally Intensive Statistics
  • Bayesian Statistics
  • Image Analysis

The main focus of my research is the development of statistical methods for the localization and detection of disease genes in genome-wide association studies. These studies consist of measurements on thousands of individuals at up to 1 million locations throughout the genome. We aim to develop powerful methods that can extract the signal of association but at the same time account for the many confounding factors that affect these studies. Recently this has involved working on genotype inputation and haplotype phase inference, genotype calling algorithms, detection of copy number variants, fine mapping, non-parametric association tests, detection of gene-gene interactions, algorithms for the detection and characterization of population structure, phenotype imputation, multi-phenotype analysis, tensor decomposition and multi-omic data-integration methods.

I have played key roles in several high-profile international collaborative research projects.

I collaborate with the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain on research in the area of imaging-genetics.

Selected Publications