McVean Group

Selected Publications

2009

McVean G (2009).A genealogical interpretation of principal components analysis. PLoS Genet. e1000686.
Goriely A, Hansen RM, Taylor IB, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Meyts ER, Wilkie AO (2009). Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders adn testicular tumours. Nat. Genet. 41:1247-1252.
The IMAGEN Consortium (2009). Mapping of multiple susceptibility variants within the MHC regions for 7 immune-mediated diseases Proc. Natl. Acad. Sci. USA 106:18680-18685.

2008

Myers S, Freeman C, Auton A, Donnelly P, McVean G(2008). A common sequence motif associated with recombination hotspots and genome instability in humans. Nat. Genet. 40:1124-1129.
Leslie S, Donnelly P and McVean G (2008). A statistical method for predicting classical HLA alleles from SNP data. Am. J. Hum. Genet. 82:48-56.
Stone GN, Atkinson RJ, Rokas A, Aldrey JL, Melika G, Acs Z, Csoka G, Hayward A, Bailey R, Buckee C, McVean GA (2008). Evidence for widespread cryptic sexual generations in apparently purely asexual Andricus gallwasps.Mol. Ecol. 17:652-655.

2007

The International HapMap Consortium (2007). A second generation human haplotype map of over 3.1 million SNPs. Nature 449:851-61.
Gay J, Myers S and McVean G (2007). Estimating meiotic gene conversion rates from population genetic data. Genetics 177:881-94.
Auton A and McVean G (2007). Recombination rate estimation in the presence of hotspots. Genome Res. 17:1219-27.
McVean G (2007). The structure of linkage disequilibrium around a selective sweep. Genetics 175:1395-406.
Marchini J, Howie B, Myers S, McVean G, and Donnelly P (2007). A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39:906-13.
Barry AE, Leliwa-Sytek A, Tavul L, Imrie H, Migot-Nabias F, Brown SM, McVean GA, and Day KP (2007). Population genomics of the immune evasion (var) genes of Plasmodium falciparum. PLoS Pathog. 3:e34.
Mu J, Awadalla P, Duan J, McGee KM, Keebler J, Seydel K, McVean GA, and Su XZ (2007). Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nature Genet. 39:126-130.
McVean G (2007). Linkage disequilibrium, recombination and selection. In The Handbook of Statistical Genetics. (Eds: Balding DJ, Bishop M, and Cannings C). Third edition. Wiley.

2006

Spencer CC, Deloukas P, Hunt S, Mullikin J, Myers S, Silverman B, Donnelly P, Bentley D, and McVean G (2006). The influence of recombination on human genetic diversity. PLoS Genet. 2:e148.
McVean G and Spencer CC (2006). Scanning the human genome for signals of selection. Curr. Opin. Genet. Dev. 16:624-629.
de Bakker PI, McVean G et al. (2006). A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat. Genet. 38:1166-1172.
Myers S, Spencer CC, Auton A, Bottolo L, Freeman C, Donnelly P, and McVean G (2006). The distribution and causes of meiotic recombination in the human genome. Biochem. Soc. Trans. 34:526-530.
Gregory SG et al. (2006). The DNA sequence and biological annotation of human chromosome 1. Nature 441:315-321.
Wilson DJ and McVean G (2006). Estimating diversifying selection and functional constraint in the presence of recombination. Genetics 172:1411-1425.
Hanchard NA, Rockett KA, Spencer C, Coop G, Pinder M, Jallow M, Kimber M, McVean G, Mott R, and Kwiatkowski DP (2006). Screening for recently selected alleles by analysis of human haplotype similarity. Am. J. Hum. Genet. 78:153-159.

2005

Myers C, Bottolo L, Freeman C, McVean G and Donnelly P (2005). A fine-scale map of recombination rates and hotspots across the human genome. Science 310:321-324.
The International HapMap Consortium (2005). A haplotype map of the human genome. Nature 437:1299-1320.
McVean G, Spencer CC and Chaix R (2005). Perspectives on human genetic variation from the HapMap project. PLoS Genet. 1: e54.
McVean GA and Cardin N (2005). Approximating the coalescent with recombination. Phil. Trans. R. Soc. Lond. 360:1387-1393.
Mu J, Awadalla P, Duan J, McGee KM, Joy DA, McVean GA, and Su XZ (2005). Recombination hotspots and population structure in Plasmodium falciparum. PLoS Biol. 3:e335.
Wilson DJ, Falush D and McVean G (2005). Germs, genomes and genealogies. Trends Ecol. Evol. 20:39-45.
Winckler W, Myers SR, Richter DJ, Onofrio RC, McDonald GJ, Bontrop RE, McVean GAT, Gabriel SB, Reich D, Donnelly P and Altshuler D (2005). Comparison of fine-scale recombination rates in humans and chimpanzees. Science 308:107-111.
Jolley KA, Wilson DJ, Kriz P, McVean G and Maiden MC (2005). The influence of mutation, recombination, population history, and selection on patterns of genetic diversity in Neisseria meningitidis. Mol. Biol. Evol. 22:562-569.
Goriely A, McVean GA, van Pelt AM, O'Rourke AW, Wall SA, de Rooij DG, Wilkie AO (2005). Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia. Proc. Natl. Acad. Sci. USA 102:6051-6056.
McVean GAT (2005). The evolutionary causes and consequences of base composition variation. In Statistical Methods in Molecular Evolution (Ed: Nielsen R). Springer.

2004

Harding RM and McVean G (2004). A structured ancestral population for the evolution of modern humans. Curr. Op. Genet. Devel. 14:667-674.
Jolley KA, Wilson DJ, Kriz P, McVean G and Maiden M (2004). The influence of mutation, recombination, population history, and selection on patterns of genetic diversity in Neisseria meningitidis. Mol. Biol. Evol. 22:562-569.
McVean GAT, Myers S, Hunt S, Deloukas P, Bentley DR and Donnelly P (2004). The fine-scale structure of recombination rate variation in the human genome. Science 304:581-584.
The International HapMap Consortium (2004). Integrating ethics and science in the International HapMap Project. Nat. Rev. Genet. 5:467-475.

2003

Stumpf, MP and McVean, GA (2003). Estimating recombination rates from population genetic data. Nat. Rev. Genet. 4:959-968.
Tyler-Smith, C and McVean, G (2003). The comings and goings of a Y-polymorphism. Nature Genetics 35:201-202.
Goriely A, McVean GAT, Röjmyr M, Ingermarsson B and Wilkie AOM (2003). Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line. Science 301:643-646.
The International HapMap Consortium (2003). The International HapMap project. Nature 426:789-796.

1997-2002

McVean G (2002). A genealogical interpretation of linkage disequilibrium. Genetics 162:987-991.
Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, and Altshuler D (2002). Human genome sequence variation and the influence of gene history, mutation and recombination. Nature Genetics 32:135-142.
McVean G, Awadalla P and Fearnhead P (2002). A coalescent-based method for detecting and estimating recombination from gene sequences Genetics 160:1231-1241.
Atkinson RJ, McVean GA and Stone GN (2002) Use of population genetic data to infer oviposition behaviour: species-specific patterns in four oak gallwasps (Hymenoptera: Cynipidae). Proc. R. Soc. Lond. B 269:383-390.
McVean GA (2001). What do patterns of genetic variability reveal about mitochondrial recombination? Heredity 87:613-620.
Charlesworth D, Charlesworth B and McVean GA (2001). Genome sequences and evolutionary biology, a two-way interaction. Trends Ecol. Evol. 16:235-242.
McVean GA and Vieira J (2001). Inferring parameters of mutation, selection and demography from patterns of synonymous site evolution in Drosophila. Genetics 157:245-257.
McVean GA and Charlesworth B (2000). The effects of Hill-Robertson interference between weakly-selected mutations on patterns of molecular evolution and variation. Genetics 155:929-944.
McAllister BF and McVean GA (2000). Neutral evolution of the sex-determining gene transformer in Drosophila. Genetics 154:1711-1720.
McVean GA and Hurst GDD (2000). Evolutionary lability of context-dependent codon bias in bacteria. J. Mol. Evol. 50:264-275.
McVean GAT and Charlesworth B (1999). A population genetic model for the evolution of synonymous codon usage: patterns and predictions. Genet. Res. 74:145-158.
Hurst LD and McVean GT (1998). Do we understand the evolution of genomic imprinting? Curr. Opin. Genet. Dev. 8:701-708.
McVean GT and Hurst LD (1997). Molecular evolution of imprinted genes: no evidence for antagonistic coevolution. Proc. R. Soc. Lond. B 264:739-746.
McVean GT and Hurst LD (1997). Evidence for a selectively favourable reduction in the mutation rate of the X chromosome. Nature 386:388-392.