Garrett Hellenthal

Department of Statistics
University of Oxford
1 South Parks Rd
Oxford, UK
OX1 3TG

hellenth@stats.ox.ac.uk


Background

I am a postdoctoral research assistant working in the Statistics Department at the University of Oxford under the supervision of Professor Jotun Hein (since 2006). I received my undergraduate degree, BS-Mathematics, at Santa Clara University in 2001. I received my PhD in Statistics at the University of Washington (with an emphasis in statistical genetics) under the supervision of Dr. Matthew Stephens in 2006, with my thesis on the development of a new statistical model for estimating rates of gene conversion using Single-Nucleotide-Polymorphism (SNP) data.


Research Interests

My main research interests involve applications of statistical methodology (Bayesian and otherwise) to genetics data. Presently my chief project involves the development and application of genomewide association methods and analyses, involving an international collaboration with the University of Oxford (England), deCODE Genetics (Iceland), the University of Aarhus BiRC (Denmark), and Radboud University Nijmegen Medical Centre (Netherlands). Other projects include the study of fine-scale meiotic recombination rates and inferring patterns of admixture in modern humans using genetics data.


Selected Talks & Posters

Inferring Human Colonization History Using a Copying Model (work with D. Falush, S. Myers) Society of Molecular Biology and Evolution (SMBE) Annual Meeting 2008, Barcelona (June 6, 2008)

Inference of the peopling of the world under sequential bottlenecks with admixture (work with D. Falush) American Society of Human Genetics (ASHG) Annual Meeting 2007, San Diego (Oct 27, 2007)

Testing SNPs Imputed with HapMap Data Polygene Group Meeting, deCODE genetics (June 4, 2007)

Exploring Rates and Patterns of Variability in Gene Conversion and Crossover in the Human Genome (work with M. Stephens) Mathematical Biology Seminar, University of Oxford (Jan 16, 2007)

Estimating crossover recombination and gene conversion rates from the human genome (work with M. Stephens) Evolution and Population Genetics Seminar, University of Washington (Jan 31/Feb 2, 2006)

msHOT: Simulating Crossover and Gene Conversion Hotspots with the ms Simulator (work with M. Stephens) American Society of Human Genetics (ASHG) Annual Meeting 2006, New Orleans (Oct 9, 2006) (poster here)

Genome-wide variation in rates of gene conversion and crossver (work with M. Stephens) American Society of Human Genetics (ASHG) Annual Meeting 2005, Salt Lake City (Oct 28, 2005) (poster here)

A New Method For Estimating Rates of Gene Conversion from Population Data (work with M. Stephens) Western North Atlantic Region (WNAR) Annual Meeting 2005, University of Fairbanks (June 23, 2005)


Publications

Hellenthal, G; Auton, A.; and Falush, D (2008) Inferring Human Colonization History Using a Copying Model. PLoS Genetics 4(5): e1000078.

Hellenthal, G and Stephens, M (2007) msHOT: modifying Hudson's ms simulator to incorporate crossover and gene conversion hotspots. Bioinformatics 23(4): 520-521. (msHOT program available here)

Hellenthal, G and Stephens, M (2006) Insights into recombination from population genetic variation. Current Opinion in Genetics & Development 16: 565-572.

Hellenthal, G; Pritchard, J.K.; and Stephens, M (2006) The Effects of Genotype-Dependent Recombination, and Transmission Asymmetry, on Linkage Disequilibrium. Genetics 172: 2001-2005.

Crawford, D.C.; Bhangale, T.; Li, N.; Hellenthal, G; Rieder, M.J.; Nickerson, D.A.; and Stephens, M (2004) Evidence for substantial fine-scale variation in recombination rates across the human genome. Nature Genetics 36(7): 700-706.

Here is my CV.