ABangle

A tool for calculating and analysing the VH-VL orientation in antibodies.


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Below are animations of the five angles and distance that define the absolute VH-VL orientation in antibodies. In each image the VH domain is coloured green and the VL domain cyan. The Chothia CDRs are coloured red.


J. Dunbar, A. Fuchs, J. Shi, CM. Deane, ABangle: Characterising the VH-VL orientation in antibodies, PEDS, 2013 [Paper Link]

HL
(torsion)

HC1
(tilt)

HC2
(twist)

dc
(distance)

LC1
(tilt)

LC2
(twist)