I am Yoonjoo Choi doing a DPhil study in Oxford Protein Informatics Group (OPIG) under Dr Chrlotte Deane's supervision. I am a member of St Cross college, Oxford University.
My main research is on the protein loop structure prediction. A loop is an element of secondary structure. Loops are generally located in the protein's surface and solvent exposed areas and they are known to be very difficult to predict.
Especially protein structure prediction by homology modelling, which predicts protein structure from existing similar sequences and structures in databases, has been very successful. However, loop structure prediction still remains a notoriously difficult problem.
Recently I found that when a loop is physically and geometrically constrained (by regular secondary structures of the loop terminal regions), the local sequence is a primary determinant of its structure. Therefore, loop structure prediction is considered to be a mini protein folding problem.
My research Interests are:
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Last
updated 26/Nov/2010