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Gulbenkian

Comparative and Integrative Biology

This is a one-week course taught by Jotun Hein and Rune Lyngsø.  Examples of projects can be found at Projects. Preparation of the project discussion will take 4-8 hours.  Beyond this the course should be self-contained.

Day 1: Molecular Evolution

9.00-10.15   Lecture: Models of Sequence Evolution and Statistical Alignment

10.30-12.00 Practical: Molecular Evolution (Phylogenies – PHYLIP+)

2.00-3.30     Lecture: Molecular Evolution & Comparative Genomics

3.30-5.00     Student Activity: Prepare projects

Day 2: Population Biology and Mapping

9.00-10.00   Lecture: Population Genetics and Gene Genealogies

10.00-11.00 Exercise:  Jukes-Cantor and Rate Matrix

11.00-12.00 Lecture: Inferring Recombination Histories

2.00-3.30     Practical: DNA Sequence Analysis (PAML Phase +)

3.30-5.00     Student Activity: Prepare projects

Day 3: Integrative Genomics (IG)

9.00-10.15   Lecture: High Throughput Data, the structure of IG, GF

10.30-12.00 Practical: Statistical Alignment & Footprinting

2.00-3.30     Lecture (L): Grammars and RNA Prediction

3.30-5.00     Student Activity: Prepare projects

Day 4: Integrative Genomics (IG)

9.00-10.00   Lecture: Networks and other concepts

10.00-11.00 Exercise: Stochastic Context Free Grammars

11.00-12.00 Lecture: Concepts, Data Analysis and Functional Studies

2.00-3.30     Practical:  Detecting Recombinations

3.30-5.00     Student Activity: Prepare projects

Day 5: Project Discussion/Presentation

9.00-10.00   Project 1 – Population Genomics: 1000 genomes

11.00-12.00 Project 2 – Comparative Genomics: Signals

2.00-3.00     Project 3 – Integrative Genomics: Basic data types

3.00-4.00     Exercise:   Statistical Alignment

4.00-5.00     Project 4 – Comparative Biology: Networks