Modelling evolution of protein secondary structure topologies
Central to structure analysis is “How does a structure evolve?” We propose a simpler topological model where the structure has been reduced to a description of secondary elements, their relationship and length. Such evolutionary models can be used either just to explore the probability of observed structures and the frequency with which different structures evolve into each other. This of interest since the existence of such a process can shed light on problem on whether the distribution observed among existing protein structures are an evolutionary accident or a structural necessity.
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