Quantifying the Structural Value of Evolution
<p>The last few years have seen the rise of comparative genomics to become a key approach to interpreting genomic information. For instance in gene finding, this was originally done for the species of one genome only, that was scanned and regions with coding characteristics was predicted to code. With the advent of more mammalian genomes, this is done with more aligned genomes and the single genome is now complemented with the observation of how different regions evolve. Since coding regions evolve differently from non-coding regions, this will increase reliability of coding prediction. The question to be addressed in this project is to quantify the value of observing a single genome, relative to observing the genome evolve for a specified period. The comparative principle is used on several problems (also RNA or protein secondary structure prediction) and the question is likely to have different answers in different contexts.</p>
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