Fine Scale Regulatory Annotation of a Gene

Acquiring knowledge of a gene is central in interpretation of what it does.  A gene is close to the “the atom” of molecular biology (Keller, 2002) and must be annotated in terms of structure, selection profile, constraints, regulatory signals and its relation to other genes.  In its extreme form, this necessitates understanding of the complete organism as a gene is part of a large interacting network of genes and signals.  So making restrictions of this problem to define a worthwhile and still challenging problem is necessary. This project focuses on the identification and the characterisation of regulatory elements, which is likely to be a major challenge for quite some time to come and this project would easily scale to a complete PhD.  However, it is also possible to formulate a pilot version, that is of interest in itself.