Genome Analysis and Bioinformatics Group

The Genome Analysis group is headed by Professor Jotun Hein.

Current Research Areas

We are working on a variety of topics, but underlying themes are evolution, population genetics, comparative genomics, integrative genomics and systems biology.  Within these fields we have focus on:

Sequence Analysis, Genome Annotation and Statistical Alignment

Although this is a classic field, there are still plenty of challenges due to the vast increase in sequence data  

Phylogenies, Pedigrees and Recombination

Another classic field with many new questions arising due to new data types 

Integrative Genomics and Data Fusion

Disease studies are quickly moving from looking at single data types (variation data, genomes, expression data, proteomics..) to attempting a combined analysis.  This poses many new modeling tasks, but also questions about the limitations of the present data sets in terms of functional characterization individual mutations 

Comparative Biology

With the great successes of comparative genomics and population genetics, it is clear that a long series of data is appearing on higher levels, like networks, shape, behaviour and more.  These must be modelled evolutionarily to be analyzed properly.  A large coming field is how to transfer knowledge from model organisms to humans.


Work ranges from developing theoretical models, over algorithmic and statistical treatment of open problems, data analysis to implementation of methods developed.

More detailed information can be found on these pages:

  • Personnel - this list includes present, associated and past members of the group
  • Publications - lists most of our publications
  • Grants - lists the scientific contents of funded and some not-funded proposals that we intend to pursue
  • Projects - lists ideas for projects that could last from summer projects to full DPhils or more.  This should give you a good idea of which topics we find interesting
  • Activities - we arrange workshops, talks and lecture series related to our research areas
  • Software - we have developed a series of programs that can be downloaded or accessed from this site
  • Teaching - we teach computational biology, systems biology, comparative genomics and population genetics at DTC LSI and DTC Sysbio.  Lectures, exercises, practicals and projects can be downloaded from the corresponding webpages
  • Recent Talks 
  • Collaborations