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Genome Analysis & Bioinformatics Group

This group is headed by Professor Jotun Hein who joined the Department of Statistics in the autumn of 2001.

Current Research Areas

We are working on a variety of topics, but underlying themes are evolution, population genetics, comparative genomics, integrative genomics and systems biology.  Within these fields we have focus on:

Sequence Analysis, Genome Annotation and Statistical Alignment
Although this is a classic field, there are still plenty of challenges due to the vast increase in sequence data  

Phylogenies, Pedigrees and Recombination
Another classic field with many new questions arising due to new data types 

Integrative Genomics and Data Fusion
Disease studies are quickly moving from looking at single data types (variation data, genomes, expression data, proteomics..) to attempting a combined analysis.  This poses many new modeling tasks, but also questions about the limitations of the present data sets in terms of functional characterization individual mutations 

Comparative Biology
With the great successes of comparative genomics and population genetics, it is clear that a long series of data is appearing on higher levels, like networks, shape, behaviour and more.  These must be modelled evolutionarily to be analyzed properly.  A large coming field is how to transfer knowledge from model organisms to humans

 
Work ranges from developing theoretical models, over algorithmic and statistical treatment of open problems, data analysis to implementation of methods developed.

More detailed information can be found on these pages:

Personnel - this list includes present, associated and past members of the group

Publications - lists most of our publications

Grants - lists the scientific contents of funded and some not-funded proposals that we intend to pursue

Projects - lists ideas for projects that could last from summer projects to full DPhils or more.  This should give you a good idea of which topics we find interesting

Activities - we arrange workshops, talks and lecture series related to our research areas

Software - we have developed a series of programs that can be downloaded or accessed from this site

Teaching - we teach computational biology, systems biology, comparative genomics and population genetics at DTC LSI and DTC Sysbio.  Lectures, exercises, practicals and projects can be downloaded from the corresponding webpages

Recent Talks 

Collaborations


Contact Details

We are located on the second and third floors of the Henry Wellcome Building of Gene Function on South Parks Road in the University Science area (building 24 on the map). Our Postal address is:

The Genome Analysis & Bioinformatics Group
Oxford Centre for Gene Function
Department of Statistics, Oxford University
1 South Parks Road
Oxford OX1 3TG
United Kingdom