Publications

Papers

A common sequence motif associated with recombination hot spots and genome instability in humans. Nature genetics (24 Aug 2008) (with C.Freeman, A.Auton, P.Donnelly, G.McVean)

Long-range LD can confound genome scans in admixed populations. Am J Hum Genet (8 July 2008) 83(1):132-5 (with A.L.Price, M.E.Weale, N.Patterson, A.C.Need, K.V.Shianna, D.Ge, J.I.Rotter, E.Torres, K.D.Taylor, D.B.Goldstein, D.Reich

Can one learn history from the allelic spectrum?  Theor Popular Biology (May 2008) 73(3):342-8 (with C.Fefferman and N.Patterson)

Estimating meiotic gene conversion rates from population genetic data.  Genetics (2007) 177(2):881-94 (with J.Gay and G.McVean)

A new multipoint method for genome-wide association studies by imputation of genotypes.  Nature Genetics (July 2007) 39(7):906-13 (with J. Marchini, B. Howie, G. McVean and P. Donnelly)

Multiple regions within 8q24 independently affect risk for prostrate cancer.  Nature Genetics (May 2007) 39(5):638-44 (with C.A.Haiman, N.Patterson, M.L.Freedman, M.C.Pike, A.Waliszewska, J.Neubauer, A.Tandon, C.Schirmer, G.J.McDonald, S.C.Greenway, D.O.Stram, L.LeMarchand, L.N.Kolonel, M.Frasco, D.Wong, L.C.Pooler, K.Ardlie, I.Oakley-Girvan, A.S.Whittemore, K.A.Cooney, E.M.John, S.A.Ingles, D.Altshuler, B.E.Henderson and D.Reich)

Live hot, die young: transmission distortion in recombination hotspots.  PloS Genet. (2007) (with G.M.Coop)

The influence of recombination on human genetic diversity. PLoS Genet. (22 Sept. 2006) 2(9) (with C.C.A.Spencer, P.Deloukas, S.Hunt, J.Mullikin, B.Silverman, P.Donnelly, D.Bentley and G.McVean)

A model-based approach to capture genetic variation for future association studies.  Genome Research (Jan 2007) 17(1):88-95 (with S.Eyheramendy, J.Marchini, G.McVean and P.Donnelly)

The distribution and causes of meiotic recombination in the human genome.  Biochem. Soc. Trans. (Aug 2006) 34(Pt 4):526-30 (with C.C.Spencer, A.Auton, L.Bottolo, C.Freeman, P.Donnelly and G.McVean)

A fine-scale map of recombination rates and hotspots across the human genome.  Science (14 Oct 2005) 310 (5746):321-4 (with L.Bottollo, C.Freeman, G.McVean and P.Donnelly)

Human recombination hot spots hidden in regions of strong market association.  Nature Genetics (2005) 37, 601-606 (with A.J.Jeffreys, R.Neumann, M.Panayi and P.Donnelly)

Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees.  Science (1 April 2005) 308 (5718):107-11 (with W.Winckler, D.J.Richter, R.C.Onofrio, G.J.McDonald, R.E.Bontrop, G.McVean, S.B.Gabriel, D.Reich, P.Donnelly and D.Altshuler)

Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots.  Genetics (Aug 2004) 167(4):2067-81 (with P.Fearnhead, R.M.Harding, J.A.Schneider and P.Donnelly)

The fine-scale structure of recombination rate variation in the human genome.  Science (23 April 2004) 304(5670):581-4 (with G.A.McVean, S.Hunt, P.Deloukas, P.Bentley and P.Donnelly)

Bounds on the minimum number of recombination events in a sample history Genetics (Jan 2003) 163(1):375-94 (with R.C.Griffiths)

With the International HapMap Consortium:

A second generation human haplotype map of over 3.1 million SNPs.  Nature (2007) 449(7164):851 -61

A haplotype map of the human genome.  Nature (2005) 437(7063):1299-320 

Integrating ethics and science in the international HapMap Project.  Nature Reviews Genetics (2004) 5 467-475

The International HapMap project.  Nature (2003) 426 789-796