Professor Chris Holmes

Professor of Biostatistics

Fellow of St Anne's College

+44 (0)1865 285874 (Direct)
+44 (0)1865 272865 (Department)
+44 (0)1865 272875 (PA)
cholmes at

Research interests
Bayesian Statistics; Stochastic Simulation; Markov chain Monte Carlo; Pattern Recognition; Spatial Statistics; Statistical Genetics; Statistical Genomics; Genetic Epidemiology.

About my research
I have a broad interest in the theory, methods and applications of statistics and statistical modelling. My background and beliefs lie in Bayesian statistics which provides a unified framework to stochastic modelling and information processing. I am particularly interested in pattern recognition and nonlinear, nonparametric methods.

Biographical sketch
I moved to Oxford from Imperial College London in February 2004. At Imperial College I studied for my doctorate in Bayesian statistics, investigating novel nonlinear pattern recognition methods. This was followed by a post-doctoral position and then a lectureship at Imperial. Previous to this I worked in industry for a number of years researching in scientific computing, developing techniques for real-time pattern recognition models in defence and SCADA (Supervisory Control and Data Acquisition) systems. My current research is focussed on applications and statistical methods development in the genomic sciences and genetic epidemiology. I hold a programme leaders grant in Statistical Genomics from the Medical Research Council.

Selected publications

Nicholson G, Rantalainen M, Li J, Maher A, Malmodin D, Ahmadi K, Faber J, Barrett A, Min J, Rayner N, Toft H, Krestyaninova M, Viksna J, Guha Neogi S, Dumas M-E, Sarkans U, MolPAGE Consortium, Donnelly P, Illig T, Adamski J, Suhre K, Allen M, Zondervan K, Spector T, Nicholson J, Lindon J, Baunsgaard D, Holmes, E, McCarthy and Holmes C (2011)  A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selectionPLoS Genet  7

Yau C, Papaspiliopoulos O, Roberts G and Holmes C (2011)  Bayesian non-parametric hidden Markov models with applications in genomicsJ Royal Stat Soc, Series B 73 (Part 1), 33-57

Lee A, Yau C, Giles M, Doucet A and Holmes C (2010)  On the utility of graphics cards to perform massively parallel simulation of advanced Monte Carlo methodsJ Comp & Graph Stats 19(4), 769-789

Wellcome Trust Case Consortium, Craddock N et al. (2010)  Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controlsNature April 1, 464(7289), 713-720

Yau C, Mouradov D, Jorissen N, Colella S, Mirza G, Steers G, Harris A, Ragoussis J, Sieber O and Holmes C (2010)  A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping dataGenome Biol  11(9), (R12)

Lemieux J, Gomez-Escobar N, Feller A, Carret C, Amambua-Ngwa A, Pinches R, Day F, Kyes S, Conway D, Holmes C and Newbold C (2009)  Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo cultureProceedings of the National Academy of Sciences, 106(18), 7559-7564

Giannoulatou E, Yau C, Colella S, Ragoussis J and Holmes C (2008) GenoSNP: a variational Bayes within-sample SNP genotyping algorithm that does not require a reference populationBioinformatics  24(19), 2209-2214

Jasra A, Stephens D and Holmes C (2007) Population-based Reversible Jump Markov Chain Monte Carlo. Biometrika  94(4) 787-807

Pintore, A., Speckman, P. and Holmes, C.C. (2006) Spatially adaptive smoothing splines. Biometrika , 96, 1, pp 113-125

List of publications