To configure alpine so that you can send and receive email make sure the following values are stored in your .pinerc file. The simplest way to configure alpine is from within alpine itself.

# alpine
S                            [for setup]
C                            [for config]

then set up the following values

SMTP Server (for sending) =
Inbox Path                = {}INBOX

where username is replaced by your username. Save these values and quit alpine. This is the most secure set up. Now restart alpine. You will need to enter your password, and the enter it again, the first time you send a message in each alpine session.